Points against their use depend on the side effects due to the deep suppression of estrogen production, like hot flashes and bone loss, often needing the use of add-back therapy for long treatments (when more than 6 months long), consisting of supplementation of hormones to reduce these negative consequences [66]
In short-term trials, particularly those involving HIV patients experiencing muscle wasting, the hormone has been administered in doses up to 0.1mg per kg of body weight for up to three months
COMT SNPs, inadequate nutrient cofactors, or a sluggish liver can slow this process, contributing to higher levels of circulating estrogen
Tsaousidou E, Paeger L, Belgardt BF, Pal M, Wunderlich CM, Brnneke H, Collienne U, Hampel B, Wunderlich FT, Schmidt-Supprian M, Kloppenburg P, Brning JC (2014) Distinct roles for JNK and IKK activation in Agouti-related peptide neurons in the development of obesity and insulin resistance