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Research in cell and animal models demonstrates its capacity to suppress NF-kB activation, reduce pro-inflammatory cytokine release including IL-1b, TNF-alpha, and IL-6, and interact with melanocortin receptors on immune and intestinal epithelial cells

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However, the study included a small number of participants and a shorter follow up time of only 48 weeks compared to other RCTs studying GLP-1 agonists