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In patients with type 2 diabetes mellitus, treatment with semaglutide injection 1 mg resulted in reductions in glucose in terms of absolute change from baseline and relative reduction compared to placebo of 29 mg/dL (22%) for fasting glucose, 74 mg/dL (36%) for 2-hour postprandial glucose and 30 mg/dL (22%) for mean 24-hour glucose concentration

The approval of orforglipron signals both a shift toward more accessible obesity treatments and a test case for the FDAs new accelerated review pathway

His take on the impact of GLP-1s on CGM adoption was strongly positive, describing it as the brightest future imaginable and expecting it to be standard of care in 3-4 years as a tool for tracking glucose variability, time-in-range, and a way to encourage behavioral change, the analysts said

This survival mechanism protected humans during famines but complicates modern weight loss efforts