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Frente al Melanotan I (afamelanotida), un anlogo lineal de -MSH con mayor selectividad por MC1R y por tanto un perfil centrado en la pigmentacin con menos efectos centrales desarrollado clnicamente para la protoporfiria eritropoytica, el Melanotan II es cclico, ms potente y activa adems MC4R, sumando los efectos sexuales y sobre el apetito

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2.8 Histological staining Ileal tissues underwent 4% paraformaldehyde fixation followed by paraffin embedding and sectioning (5 m) for H&E staining to evaluate villus architecture