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One of the challenges is that glutathione production decreases naturally as we age
, decreased compared to placebo
Recently published data purporting to resolve this question shows that over-expressing GAD but not Aldh1a1 rescues GAT1-knockout DA/GABA neuron GABAergic IPSCs, disproving a role for Put-GABA de novo synthesis in striatal DA/GABA neurons (Melani and Tritsch, 2022)
vegans and vegetarians, due to inadequate iron intake and the lower bioavailability of iron from plants
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