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Glucagon receptor activation in the liver stimulates glycogenolysis and gluconeogenesis, but more relevantly for metabolic research, it also activates brown adipose tissue thermogenesis and increases fatty acid oxidation in hepatocytes

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Starting at 8 weeks of age, male and female cell GLP-1R WT ( Glp-1r cell+/+ [WT]) and KO ( Glp-1r cell/ [KO]) mice were fed a high-fat diet (HFD) for 6 weeks to produce an obese insulin-resistant phenotype (Figure 1A)

This suggests that hyperglycemia suppressed catalase expression [92,93,94]