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Notably, bi-allelic MC4R mutation carriers had long-term outcomes as poor as those with bi-allelic LEPR or POMC mutations, suggesting that biallelic mutations in LMP genes generally lead to more severe impairment of surgical efficacy compared to heterozygous mutations

This is because the medication is typically started at a lower dose and increased slowly over several weeks

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It is one of the most extensively studied compounds in angiogenesis and wound-healing research, with models focusing on tendon-to-bone healing, new blood-vessel formation, and gastrointestinal tissue repair