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In mid-2024, the Endocrine Society warned that online prescribing of compounded GLP-1s poses patient safety risks and undermines public confidence in obesity care. The organization called for stricter verification of clinicians and for oversight of digital compounding networks that have limited traceability or pharmacovigilance. Their concern echoed that of the FDA , which, after investigating multiple adverse-event reports linked to unapproved semaglutide, issued formal warnings to both compounders and telehealth distributors

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Unlike orlistat, which blocks fat absorption, or phentermine, which is a stimulant-based appetite suppressant, GLP-1 receptor agonists address hunger and satiety at the hormonal level, targeting a fundamental aspect of overeating