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A phase 2 trial of semaglutide 2.4 mg in biopsy-confirmed MASH showed resolution of steatohepatitis without worsening of fibrosis in 59% of patients at 72 weeks, versus 17% on placebo [12]
doi: 10.1016/j.nbd.2009.07.030 79
It has not spoiled
The most likely explanation is that semaglutide side effects, particularly dehydration from GI symptoms , indirectly increase clot risk in some users, while the drug direct anti-platelet and anti-inflammatory effects provide protection in others
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