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During the progression of liver disease, OCTN1 and OCTN2 appear to serve as binding sites for various drugs that influence hepatic steatosis, such as Cynara cardunculus extract, clozapine, and olanzapine

Nat Metab (2022) 4:389403

Consequently, BCL-2 family inhibitors have been identified to function as senolytics, including ABT-737, ABT-263 (Navitoclax), A-1331852, and A-1155463

As research progresses, the hope is that some of these biologic modalities will enter clinical practice, especially in high-stakes surgeries (transplantation, cardiac surgery, major trauma) where current supportive care is not always sufficient to prevent organ injury