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Key Takeaway Eli Lilly is not standing still
Fatigue is a recognised adverse reaction with these diabetes and weight management treatments, though its severity and duration vary considerably between individuals
These symptoms are primarily due to the mode of action of GLP-1 RAs on the gut, as a GLP-1 may directly or indirectly regulate electrolyte and fluid homeostasis by influencing feeding and drinking behavior as well as electrolyte transport in the kidneys and gastrointestinal tract [25]
the inhibition of adenylyl cyclases, as a readout
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