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We further determined the impact of ERMCS-localised GLP-1R signalling on -cell function by analysing acute insulin secretion responses and -cell survival to ER stress downstream of GLP-1R stimulation in SPHKAP RNAi-treated versus Control WT INS-1 832/3 cells

Research published in JCI Insight describes tirzepatide as an "imbalanced and biased dual agonist," meaning it actually engages the GIP receptor more potently than the GLP-1 receptor

Side effects associated with Saxenda: Headache Dizziness Fatigue Fever (common in teens) Nausea Vomiting Diarrhea Constipation Gastroenteritis (inflammation of the stomach and intestines) Upset stomach (dyspepsia) Stomach pain Low blood sugar (hypoglycemia) Change in enzyme (lipase) levels in your blood Mild allergic reaction (rash, itching) Severe allergic reaction (rare cases) Increased heart rate (heart palpitations, chest pain) Changes in blood pressure and other cardiovascular issues Redness, pain, or swelling at the injection site Lawsuits allege that Novo Nordisk, the manufacturer of Saxenda, failed to warn of adverse side effects related to the long-term use of the drug, including the potential for gastroparesis

Nora Volkow, also said retrospective analyses of electronic health records showed patients with diabetes who were prescribed GLP-1 drugs such as semaglutide had significantly better health outcomes related to cannabis use disorder, compared with those on other diabetes treatments