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A landmark 2023 study published in JAMA found that GLP-1 agonist users experienced increased risks of gastrointestinal adverse events (with gastroparesis risk elevated compared to patients using other diabetes medications), while a 2024 case report in PMC documented the strong relationship between semaglutide use and gastroparesis symptoms that resolved only after drug discontinuation
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Researchers are still learning about the full effects of semaglutide on reproductive hormones, and more studies are needed to answer all the questions
Foods to Avoid or Limit High-Fat Foods Fatty foods are the number one culprit for worsening nausea and digestive discomfort on GLP-1 medications
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