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Abbreviations ACADS : Short-chain specific acyl-CoA dehydrogenases ACOX : Acyl-coenzyme A oxidese ACSS : Acyl-CoA synthetase short-chain family ALDOC : Aldolase C BEX2 : Brain expressed X-linked 2 BRD4 : Bromodomain-containing protein 4 BRD9 : Bromodomain-containing protein 9 CALM3 : Calmodulin like protein 3 CAMs : Cell adhesion molecules CBP : CREB-binding protein CDYL : Chromodomain Y-like CRC : Colorectal cancer DGCs : Differentiated glioblastoma cells DPF : Double PHD zinc finger dsRNA : Double-stranded RNA ECHS1 : Enoyl-CoA hydratase ENO1 : Enolase 1 ENO2 : Enolase 2 ETS1 : E26 transformation-specific 1 GBM : Glioblastoma GCDH : Glutaryl CoA dehydrogenase GCN5 : General Control Non-derepressible 5 GSCs : Glioblastoma stem cells GSH : Glutathione HATs : Histone acetyltransferases HCC : Hepatocellular carcinoma HCTs : Histone crotonyltransferases HDAC : Histone deacetylases hMOF : Human MOF HNRNPA1 : Heterothymic nuclear ribonucleoprotein A1 HSP90AB1 : Human heat shock protein 90 alpha family class B member 1 Kbhb : -Hydroxybutyrylation Kbu : Butyrylation Kbz : Benzoylation Kcr : Crotonylation Kcr : Lysine crotonylation Kglu : Glutarylation Kla : Lactylation Kpr : Propionylation Ksucc : Succinylation LNCaP : Lymph node carcinoma of the prostate MCM6 : Minichromosome maintenance 6 MTHFD1 : Methylenetetrahydrofolate reductase NDP52 : Nuclear domain 10 protein 52 NEAT1 : Nuclear enriched abundant transcript 1 NSCLC : Non-Small cell lung cancer NSCs : Neural stem cells OSCC : Oral squamous cell carcinoma PCa : Prostate cancer PCAF : P300/CBP-Associated Factor PDAC : Pancreatic ductal adenocarcinoma PDH : Pyruvate dehydrogenase PDHK1 : Pyruvate dehydrogenase kinase isoform 1 PGD : 6-Phosphogluconate dehydrogenase PGK1 : Phosphoglycerate kinase 1 PKA : Protein kinase A PPP : Pentose phosphate pathway PRKACA : Proteins closely related to protein kinase A PTBP1 : Polypyrimidine tract-binding protein 1 PTMs : Post-translational modification RRM2 : Resistance-related genes 2 SASP : Senescence-associated secretory phenotype SEPT2 : Septin2 SIRT : Sirtuin SLC7A2 : Solute carrier family 7 member 2 TAF1 : TBP-Associated Factor 1 TEs : Transposable elements TKT : Transketolase TSS : Transcription start sites References Aghdassi A, Sendler M, Guenther A, Mayerle J, Behn C-O, Heidecke C-D, et al

SURMOUNT-1 SURMOUNT-1 was a 72-week trial designed to test the weight loss efficacy of tirzepatide in patients with overweight or obesity but no T2D