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The mechanism is generally telogen effluvium driven by rapid weight loss rather than a direct effect of tirzepatide, similar to what is seen after bariatric surgery or any aggressive caloric deficit

Reductions in gut microbiota-derived metabolite trimethylamine N-oxide in the circulation may ameliorate myocardial infarction-induced heart failure in rats, possibly by inhibiting interleukin-8 secretion

Researchers comparing them should review the primary NNMT-inhibitor literature alongside NAD+ precursor studies directly