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Classical pro-inflammatory cytokines (IL1B, IL6, TNF) and pattern recognition receptors (TLR2, TLR4) are markedly increased, along with adhesion molecules (VCAM1, ICAM1) and chemokines (CCL2, CXCL8) that promote leukocyte recruitment and vascular injury (Falco-Holanda et al., 2021

While hair loss wasnt seen in people during studies of Rybelsus, this side effect was reported after the drug became available

The intended benefits might not be realized through oral intake