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The role of INSL-5 as an energy sensor within the colon is not restricted to the availability of SCFAs, as Insl5 expression in GF mice can also be reduced following HFD consumption, in which unabsorbed lipids provide an alternative energy source to colonocytes (168)
This rapid turnover means that maintaining therapeutic levels of GLP-1 activity requires either continuous endogenous production or pharmaceutical intervention with DPP-4-resistant analogs
GLP-1 Receptor Agonist Exposure During Pregnancy: A Systematic Review and Meta-Analysis of Adverse Pregnancy Outcomes
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