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Protein has a higher thermic effect of food compared to other macronutrients, meaning the body expends more energy digesting and metabolising protein
Furthermore, since the instability of Ala 2 is caused by degradation of DPP-4, Ala 2 may not need to be changed if the peptide is fused with albumin or Fc domain (discussed later) for long-term activity, which creates a steric hindrance to prevent the enzyme from getting close
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