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The well-known geriatrician-haematologist Larry Solomon, working at Yale University in the USA, wrote 20 years ago: if I had treated only those people who actually had too low serum B12 and elevated MMA values, then I would not have treated approximately two-thirds of the people with a favourable response to B12 supplementation (note: partly via injections, partly via oral supplementation)

Notes: Monitor kidney function daily, due to an increased risk of tubular toxicity after the first week of the trial

Most collagen interventions only do the first

While some vitamins last just a few days, others, like vitamin D, can stay in the system for months