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A 2003 double-blind placebo-controlled trial by Humbert and colleagues in Experimental Dermatology applied 5% topical ascorbic acid cream versus vehicle to the low-neck and arms of healthy women with photoaged skin for 6 months, with assessments at baseline, 3 months, and 6 months, and found that active treatment improved skin relief and silicone-replica topography and produced favorable changes on end-of-study immunohistochemistry and electron microscopy of dermal biopsies biopsy-level evidence of structural remodeling, not merely surface appearance
Were exposed to free radicals from environmental pollution, stress, overconsumption of alcohol, and other factors
Others may take slightly longer to experience noticeable changes, though clinical data shows the vast majority of participants reported some appetite changes within the first two weeks
Subcutaneous Aqueous drug particle suspension 1
