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We also demonstrate intramolecular Friedlnder macrocyclization reactionssufficiently mild to be employed on unprotected and in vitro-translated peptidesthat embed a quinoline pharmacophore directly within the peptide backbone
And its a history with its share of ignominy: In the mid-1990s, a drug that combined fenfluramine and phentermine, known as fen-phen, exploded in popularity after a single, 121-patient study showed it was effective for weight loss
Journal of the International Society of Sports Nutrition, 12 , 42
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