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Consequently, regarding the formation of multidrug resistance in tumor cells, besides acting as a detoxification enzyme though excretion of drugs to decrease pharmacological efficacy, GST can also act as an MAPK-pathway inhibitor to improve tumor-cell survival

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For example, manganese superoxide dismutase (MnSOD), a mitochondrial antioxidant enzyme, can undergo nitration of its tyrosine residues, leading to enzyme inactivation and contributing to oxidative stress and related diseases