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It also actively participates in the metabolism of cells

The condition develops gradually, often over months or years, as the body's B12 stores become depleted

As well, some people may have allergies or medical conditions that do not allow them to be a good candidate to receive vitamin B12 shots, such as kidney problems, low potassium levels, deficiencies in other vitamins such as iron or folic acid, or just an allergy or sensitivity to vitamin B12 itself

The maternal adaptive immune system raises a response against antigens on fetal red blood cells and produces anti-fetal IgG Abs with the ability to cross the placenta via FcRn-mediated transport