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54 This trial emphasized that orforglipron might provide an alternative to injectable GLP-1 receptor agonists and oral semaglutide, with the prospect of less burdensome administration to achieve treatment goals in diabetics

While the molecule remains investigational, early data indicate that its mechanistic profile may offer multiple avenues for future study

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Of those participants with GLP 1-RA exposure, 0.2% of patients received a new nAMD diagnosis during the nearly three-year period between identifying and following up patients, compared with 0.1% of patients not exposed to the drug, the study found