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Phase 1 Trials In a first-in-human, randomized, placebo-controlled, single ascending dose, phase 1 trial in healthy participants, retatrutide demonstrated a favourable safety profile (similar to other incretin-based therapies) and early signs of efficacy with dose-dependent WL [42]

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This non-essential amino acid can be transformed into glutamate and then into -ketoglutarate (KG), which like glucose-derived acetyl-CoA, is an essential fuel for the TCA cycle [ Fatty acids Fatty acids (FAs) can fuel cellular metabolism through FA oxidation (FAO), another source of acetyl-CoA, which can then be shuttled to the TCA cycle