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Do not exceed 8 shots per month
The International Diabetes Federation (IDF) reported in 2021 that the Asia Pacific region has the largest number of adults living with diabetes globally, exceeding 290 million
Furthermore, GLP-1Rs on IELs have been found to regulate the metabolic effects of GLP-1 in animal models by entrapping it, thereby reducing its systemic availability and lowering its plasma concentrations (62)
Any new or worsening symptoms after months of stable therapy should be evaluated, as these may indicate complications unrelated to expected medication effects
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