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As of 2026, the FDA allows licensed pharmacies to make these peptides with a prescription, but that is not the same as approving them as safe or effective

In a 2-year trial involving patients with type 2 diabetes mellitus (T2DM) and high cardiovascular risk, more events of diabetic retinopathy complications occurred in the patients treated with semaglutide injection (3%) compared to placebo (1.8%)

However, it has been shown to be helpful for the treatment of depression, panic disorder, polycystic ovarian syndrome, and fatty liver

Vitamin B12 deficiency, left untreated, can lead to pernicious anaemia or neurological problems