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The design works because the GLP-1 and GIP arms buffer that glucose-raising tendency, leaving glucagon free to do something useful: push up energy expenditure, encourage the liver to burn its own fat stores, and increase the rate at which the body turns over lipids
Cell 43 , 704715.e5 (2017)
Weight loss achieved through caloric restriction is accompanied by marked elevation in circulating ghrelin (145), which increases feeding drive and has therefore been ascribed as a natural defense against weight loss
This hormone plays an important role in controlling blood sugar levels
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