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Suspected adverse reactions to any medicine, licensed or unlicensed, should be reported via the MHRA Yellow Card Scheme

Those with pre-existing diabetic retinopathy should continue with the NHS Diabetic Eye Screening Programme and may require more frequent ophthalmological review, as rapid improvements in glycaemic control can occasionally worsen retinopathy temporarily

The weaker evidence is TRIUMPH-3, where hyperglycaemia was reported as an adverse event in 3.9% (9 mg) and 3.1% (12 mg) of retatrutide participants versus 13.4% on placebo