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Despite being mechanistically different, pyroptosis, ferroptosis, apoptosis, necroptosis act synergistically via shared signaling nodes in DKD, with mitochondrial ROS (mtROS) and serving as a pivotal common mediator (30, 112, 176, 207)
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Currently, sulfated phosphatidyl-ethanolamine hydroperoxide (SAPE-OOH) on the surface of ferroptotic cells is recognized as an eat-me signal, facilitating interaction with Toll-like receptor 2 (TLR2) on macrophages (129)