10.18632/oncotarget.23055 12 ChenY.MiY.ZhangX.MaQ.SongY.ZhangL.et al (2019)
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For example, GluK2 and GluK5 are expressed in the majority of hippocampal neurons, as well as in various types of interneurons (Paternain et al., 2000), GluK1 exhibits widespread expression in cerebellar cortex and olfactory bulbs during early development (Pinheiro et al., 2007), and GluK4 is mainly present in the pyramidal neurons of the DG and Cornu Ammonis 3 (CA3) region of hippocampus and in the amygdala (Lerma and Marques, 2013
But these challenges arent insurmountable