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Lancet Neurology 21, 10041060

"Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study"

Dermal edema and erythrocyte extravasation may be present, as well as spongiosis, a pseudolymphomatous reaction, and focal epidermal necrosis.43,44 Laboratory alterations Eosinophilia, in varying degrees, is one of the characteristics of the syndrome, is present in up to 95.5% of cases at some stage of the disease and may persist after the normalization of liver enzymes.32,45 Several cytokines are involved in the activation and recruitment of eosinophils