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Oral absorption is poor and first-pass metabolism heavy, so both routes land in roughly the same place
Patients with severe gastrointestinal disease (gastroparesis, inflammatory bowel disease) may have difficulty tolerating these medications
Responses differ from person to person
Melatonin can exert its effects by acting through specific cellular receptors on the plasma membrane, similar to other hormones, or through receptor-independent mechanisms that involve complex molecular cross talk with other players
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