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these drugs should not be used in patients with a personal or family history of medullary thyroid carcinoma or MEN2 Rare cases of retinopathy progression in patients with pre-existing severe diabetic retinopathy, likely related to rapid glycemic improvement Potential drug interactions related to delayed gastric emptying, which can affect absorption of other oral medications The practical approach is dose titration
Because both are investigational and years from routine availability, waiting means going untreated in the meantime
Your healthcare provider should guide any medication switch, but the decision often depends on your tolerance and results rather than the medications' chemical properties alone
But the duo, both of whom focus on disease prevention in their research, also call for more focus on the prevention and root causes of obesity and on the use of proven treatment approaches other than medication
