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Exenatide, a synthetic version of exendin-4 produced industrially, was the first GLP-1RA approved for the market [exenatide twice daily (EX-BID)], followed by a long-acting formulation that improved the delivery system [exenatide once a week (EX-QW)]
The comparison group included 33,555 patients (n = 33,555) who received dulaglutide, phentermine/topiramate, or bupropion/naltrexone and had no prior history of semaglutide use
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Rather than acting through a single mechanism, this peptide appears to coordinate multiple healing processes simultaneously, which may explain its consistent effectiveness across different wound types and tissue locations
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