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Effects of GLP-1 analogs on gastric emptying and symptoms. American Journal of Physiology , 2021
In the pivotal tesamorelin trial, IGF-1 rose by roughly 81% relative to placebo a clear pharmacodynamic signal that the peptide was engaging its target and driving the GHIGF-1 axis
This study found no evidence reasonably suggesting an association between GLP-1RA and SSIBs based on clinical characteristics, TTO, disproportionality, and co-medication analysis
When present, side effects are typically mild and transient, potentially including slight drowsiness if administered too early (easily resolved by timing adjustment), mild headaches during initial adaptation in some individuals (usually resolving within days), temporary vivid dreams as sleep architecture normalizes, or rare reports of mild dizziness upon waking in sensitive individuals
