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A 2022 commentary in Wound Repair and Regeneration stated: "Fewer than 15% of compounds showing efficacy in rodent wound models achieve statistical significance in Phase III human wound trials" [8]
Additionally, chronic infection or dysbiosis might drive peripheral inflammation that reduces the clearance of A from the brain via the glymphatic system and BBB transporters [140]
NAC may appeal to people who want to support internal glutathione synthesis, while direct glutathione may appeal to those who prefer a preformed antioxidant
E., Elliott, E
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