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Are GLP-1 medicines approved for weight loss
In a post-hoc analysis of the published SURPASS trials, the change in systolic blood pressure was greater for tirzepatide versus the comparators of the trials (tirzepatide 5 mg: -5.1 to -1.3 mmHg, tirzepatide 10 mg: -6.5 to -1.7 mmHg, tirzepatide 15 mg: -11.5 to -3.1 mmHg) [65]
At the same time, glycine is also an obligatory co-agonist at N-methyl-D-aspartate (NMDA) receptors, a type of excitatory glutamate receptor in the brain
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