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The combination of estimates from different experiments

The primary endpoint, major adverse cardiovascular events (MACE), was the time to first occurrence of a three-part composite outcome which included CV death, non-fatal myocardial infarction (MI) and non-fatal stroke

Most patients find that gastrointestinal side effects diminish substantially after the first 4-8 weeks, making persistence through this initial period worthwhile for many individuals who achieve significant glycaemic and weight benefits

semaglutide: findings from clinical trials Clinical trials have shown that in just over a year, semaglutide led to an average loss of 14.9% of overall body weight, while liraglutide led to an average loss of 8%