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In another child who accidentally ingested 400 mg/kg VPA, decreased -oxidation and markedly increased -oxidation were also observed, and the concentration of 4-en-VPA was markedly increased, although there was neither hyperammonaemia nor signs of liver dysfunction [70]

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In these settings, the glutathione pair should be integrated with lipid-peroxidation products, antioxidant-enzyme activities, inflammatory mediators, mitochondrial function, and disease-relevant phenotypes

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