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Obtaining sufficient systemic exposure of peptide-based drugs following oral administration is difficult owing to the acidic environment and presence of proteolytic enzymes in the stomach, and the limited permeability of peptides and proteins through the gastrointestinal epithelium [20, 25]

64 RENAL DYSFUNCTION AND NEPHROTOXICITY We have alluded to the potential for decreases in GSH concentration to impair GSH conjugation and modify the metabolic fate of many compounds

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In one case, a caller said they were having trouble with the pen and accidentally dialed it all the way up, giving themselves an entire month of doses at once