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The body interprets rapid fat loss as a significant stressor, releasing inflammatory mediators as part of the adaptive response

In a trial of patients with T2DM and a BMI of 27 kg/m2 or greater being treated with semaglutide injection for weight loss, clinically significant hypoglycemia (plasma glucose less than 54 mg/dL) was reported in 6.2% of semaglutide-treated patients versus 2.5% of placebo-treated patients

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When studied together, the combination is investigated for its potential to generate a more complete and organised healing response than either peptide produces independently