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11 12 This raises concerns about potential long-term effects on metabolic health, strength, and physical function
While there is some existing research on berberine as a standalone supplement, the evidence doesn't support the idea that it works as effectively as a prescription GLP-1 medication , and studies on the transdermal delivery method (absorbing supplements through the skin) for these ingredients are lacking
Of these, GLP-1 RAs are generally preferred because of their demonstrated cardiovascular benefits and potential for improved renal outcomes [2]
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