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[1] The FDA label includes a boxed warning regarding thyroid C-cell tumors and contraindicates tirzepatide in patients with personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2

Most patients on either drug don't reach either extreme, but the distribution skews differently tirzepatide pulls the curve toward Depletive, semaglutide skews toward Prime

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