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doi:10.1016/j.bcp.2018.05.003 Neelakantan H, Brightwell CR, Graber TG, et al

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The researchers reported that lowering NNMT expression changed metabolic pathway activity and energy use

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The vial format supports precise dose-response studies in cell-culture and animal models of NNMT inhibition and adipose-tissue metabolic regulation

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By increasing NAD levels and activating the SIRT1 pathway, NNMTi inhibits the activation of inflammatory signaling pathways (such as the NFB pathway), thereby reducing macrophage infiltration and inflammatory factor release

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