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Interestingly, the GLP-1 receptor agonist, dulaglutide, and the dual GLP-1 and GIP receptor agonist, tirzepatide, are both characterized by a strong delayed gastric emptying upon a single dose administration, but the effect tends to subside as gastric emptying tachyphylaxis is observed after several weeks of treatment
Similarly Krajnc et al
These combined actions result in improved glycemic control, weight reduction, and potential cardiovascular benefits, though specific cardiovascular indications vary by agent according to FDA labeling
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