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These strategies are particularly important for individuals with pre-existing osteoporosis risk factors or those experiencing rapid weight loss

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However, in a retrospective study of nearly half a million patients, semaglutide was associated with lower risk for incident (HR = 0.27) and recurrent (HR = 0.44) suicidal ideation compared with non-GLP-1 anti-obesity medications

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The time to steady state varies by medication: liraglutide reaches steady state in approximately 3 days, semaglutide and dulaglutide in 45 weeks, and exenatide extended-release in 67 weeks

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