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Both liraglutide and semaglutide were engineered to resist DPP-4 degradation, but semaglutide took the engineering significantly further
They tried a few tricks: DPP-4-resistant versions: tweaking the GLP-1 molecule so DPP-4 cant see where to cut it Fatty acid tails: causing the GLP-1 to latch onto albumin in your blood, hiding from DPP-4 Encapsulation: wrapping the molecule in protective coatings so it survives longer before being exposed to enzymes These hacks meant the drug could hang out in the bloodstream for hours, or even days, instead of minutes
van Dijk, A
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