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Important safety considerations include the risk of pancreatitis (all GLP-1 agonists carry warnings about this), gallbladder disease (more common with greater weight loss), and a caution with semaglutide in patients with pre-existing diabetic retinopathy, where rapid improvement in glucose control may temporarily worsen retinopathy
Mechanistically, GGsTop treatment led to an accumulation of serum tGSH and a depletion of cysteine in tumours (Fig
Sources: Ames BN, et al
Taken together, these findings suggest a possible positive interaction between estrogen status and GLP-1based therapy
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