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For example, in the liver affected by NAPQI, severity of injury may range from full necrosis in hepatocytes immediately around the central vein, to cells in the midzonal region that still survive, but have undergone adaptive responses as they continue to experience persistent JNK activation and oxidant stress, but have not yet reached an irreversible sustained MPT, to periportal hepatocytes that are minimally affected or undergoing successful repair

Saponins: These bitter compounds have certain anti-inflammatory and cholesterol-lowering properties

Free Radic Biol Med 34:10781088 Chatterjee A (2013) Reduced glutathione: a radioprotector or a modulator of DNA-repair activity

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